Liquid anthelmintics



Patented Mar. 15 1938 1 1 UNITED STATESRATENT OFFICE LIQUID ANTHELMINTICS Max Bockmiihl and Gustav Ehrhart, Frankforton-the-Main-liiochst, Germany, assignors to Winthrop Chemical Company, Inc., New York, N. 2., a corporation of New York No Drawing. Application November 3, 1936, Se-

rial No. 109,051. In Germany November 8, 1935 4 Claims. (Cl. 167-55) The present invention relates to liquid anthelinvention, but they are not intended to limit it mintics. thereto; the parts are by weight:

In the U. S. Patent No. 2,008,238 to Bockmiihl 1. 100 parts of chenopodium oil are dissolved et a1. there are described liquid anthelmintics in 100 parts of polyethylene oxide. 5 which contain liquid substances having an an- 2. 100 parts of carbon tetrachloride are dis- 5 thelmintic effect and an organic carboxylic acid solved in 100 parts of hydroxyethylated castor salt of a basic derivative of a fatty acid containoil.

ing at least carbon atoms. Finely dispersed 3. 50 parts of para-cymene are dissolved in emulsions may be obtained from these liquids 25 parts of polyethylene oxide and 25 parts of 10 with water or aqueous liquids which may be hydroxyethylated castor oil. 10

administered in \drinks or in capsules. 4. 50 parts of carbon tetrachloride are dis- Now we have found that solutions of anthelsolved in 50 parts of polyhydroxyethylated oleyl mintics which are also suitable for the use in alcohol. water may be prepared by using polyalkylene 5. 100 parts of trichloroethylene are dissolved oxides or their derivatives as solvents for the in 80 parts of polyethylene oxide and parts of 15 liquid anthelmintics. There may, for instance be p y yd y P 111113 fatty acid Sorbite used polyethylene oxide, i. e., the ethylene oxide ester. which is polymerized up to a wax-like consist- We claim: ency. Furthermore there may be used the hy- Liquid anthelmintics Comprising a 20 droxyethylated castor oil obtained by self-conpound selected from the group consisting of poly- 20 densation from castor oil and polyethylene oxide, lkyl ne oxide and the derivatives thereof and hydroxyethylated ricinoleic acid, polyhydroxya quid substance soluble in said comp und a d ethylated oleyl alcohol, polyhydroxyethylated known to have an anthelmintic effect, Said anpalm nut fatty acid sorbit ester; th polyhythelmintics yielding stable emulsions with water.

droxyethylated compounds named may, for in- Liquid anthelmintics mprisin poly hy- 25 stance, be obtained by the action of 10 to 20 mo- 16116 Oxide and a liquid Substance Soluble in p ylecular proportions f ethylene oxide upon one ethylene oxide and known to have an anthelmolecular proportion f the compound in ques mintic effect, said anthelmintics yielding stable fionemulsions with water.

These solvents may also be applied in mixture Llqmd anthglmmtms. cqmpnsmg hydroxy' with one another ethylated castor 011 and a liquid substance soluble According to this invention solutions of any dem hydroxyethylated castor 011 and known to have an anthelmintic efiect, said anthelmintics yieldsired concentration may easily be prepared. The mg Stable emulsions with water.

solutions may be administered in drinks or in Liquid anthelmintics comprising p01yhy 35 capsulesy be mixed with adjuvants, droxyethylated oleyl alcohol and a liquid subother desired medicines, substances which are Stance Soluble in polyhydroxyethylated oleyl Capab e 0 improving the taste, the likeqcohol and known to have an anthelmintic effect, uid anthelmintics are, for instance, ca bo etrasaid anthelmintics yielding stable emulsions with chloride, ethylene tetrachloride, ascaridol and water. 40

chenopodium oil. MAX BocKMi'n-IL.

The following examples serve to'illustrate the GUSTAV EHRI-IART. 

